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Herpes Simplex Virus 2 ICP0 Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

Figure 6

Inoculation with HSV-2 0ΔNLS imparts protective immunity against HSV-2.

(A) Mean ± sem titer of serum IgG antibody specific for HSV-2 glycoprotein D (gD2), as determined by ELISA on 1∶100 dilutions of mouse serum (n = 20 per group). (B) Mean ± sd of the frequency of survival of mice until 30 days after challenge of the left eye with a dose of 100,000 pfu/eye of HSV-2 MS (n = 8 mice per group per test×2 tests; Σn = 16 per group). A single asterisk (*) denotes p<0.05, and a double asterisk (**) denotes p<0.001 regarding the probability, p, that the survival frequency of each group was equivalent to naïve mice.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0012251.g006