Selective Serotonin Reuptake Inhibitors Potentiate the Rapid Antidepressant-Like Effects of Serotonin4 Receptor Agonists in the Rat
Figure 6
Effect of RS 67333 (1.5 mg/kg, i.p.), in combination with various SSRIs, on the time spent immobile in the FST.
The SSRIs used were A fluvoxamine (10 mg/kg, i.p.), B citalopram (10 mg/kg, i.p.), and C fluoxetine (10 mg/kg, i.p.). All data are expressed as mean ± S.E.M. of eight animals per group (except for the vehicle/RS 67333 group which comprises 12 animals), and are from an observation of 4 min duration. Rats experienced a pre-test session (15 min) 24 h before the test session. In each animal, RS 67333 (or its vehicle) and the SSRI (or its vehicle) were administered almost concomitantly (within a 30 s interval), 30 min before the test session; the sites chosen for i.p. injections were always symmetrically opposed with respect to the abdomen midline. * p<0.05 and *** p<0.001 vs vehicle/vehicle, ++ p<0.01 vs citalopram/vehicle, ‡‡‡ p<0.001 vs fluoxetine/vehicle and # p<0.05 vs vehicle/RS 67333, Tukey's test.