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Human Ovarian Reserve from Conception to the Menopause

Figure 5

Percentage of ovarian reserve related to increasing age.

The curve describes the percentage of ovarian reserve remaining at ages from birth to 55 years, based on the ADC model. 100% is taken to be the maximum ovarian reserve, occurring at 18–22 weeks post-conception. The percentages apply to all women whose ovarian reserve declines in line with our model (i.e. late and early menopause are associated with high and low peak NGF populations, respectively). We estimate that for 95% of women by the age of 30 years only 12% of their maximum pre-birth NGF population is present and by the age of 40 years only 3% remains.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0008772.g005