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Parallel Routes of Human Carcinoma Development: Implications of the Age-Specific Incidence Data

Figure 1

This graph compares two different hypotheses for the development of carcinoma with the age-specific incidence data.

The multi-stage hypothesis, as represented by the Armitage-Doll model, Equation 2 [51], and parallel route hypothesis, represented by Equation 3. The Armitage-Doll model is an approximation of the differential form of the Poisson process, Equation 1. Using this equation gives , a substantially better, but still clearly unacceptable fit. Thus, the parallel route hypothesis is clearly acceptable, while the multi-stage hypothesis is not. The error bars represent 95% confidence intervals in the measured values.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0007053.g001