Parallel Routes of Human Carcinoma Development: Implications of the Age-Specific Incidence Data
The multi-stage hypothesis, as represented by the Armitage-Doll model, Equation 2 , and parallel route hypothesis, represented by Equation 3. The Armitage-Doll model is an approximation of the differential form of the Poisson process, Equation 1. Using this equation gives , a substantially better, but still clearly unacceptable fit. Thus, the parallel route hypothesis is clearly acceptable, while the multi-stage hypothesis is not. The error bars represent 95% confidence intervals in the measured values.