CD133 Is a Marker of Bioenergetic Stress in Human Glioma
(a) Initiation of tumor formation. (b) Tumor growth restricted at the oxygen and glucose diffusion barrier. (c) Glioma ells at the edge of the tumor will be re-oxygenated by neovascularization, and grow and divide until they reach a new oxygen and nutrient diffusion barrier. (d): repetitive cycles of growth and angiogenesis occur during the progression of the tumor.