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CD133 Is a Marker of Bioenergetic Stress in Human Glioma

Figure 7

Tumor progression model:

(a) Initiation of tumor formation. (b) Tumor growth restricted at the oxygen and glucose diffusion barrier. (c) Glioma ells at the edge of the tumor will be re-oxygenated by neovascularization, and grow and divide until they reach a new oxygen and nutrient diffusion barrier. (d): repetitive cycles of growth and angiogenesis occur during the progression of the tumor.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0003655.g007