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Causal Measures of Structure and Plasticity in Simulated and Living Neural Networks

Figure 6

Comparison of Causality Values from a Traditional Conditional Granger Causality Analysis and the Computational Alternative Described in the Text.

Direct influences between N2 and N3 were recovered by both methods to allow a comparison of Geweke's subtraction method to CGC. Each point was generated from a Monte Carlo simulation of the serial simulation using randomly generated synaptic weights between 15 mV and 45 mV. This plot suggests that both methods provide results consistent with the linear region expected from the sigmoid plot shown in Figure 4. However, Geweke's subtraction method is computationally simple providing the researcher with a clear advantage in large networks especially under conditions where the structural connectivity is known to be serially arranged.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0003355.g006