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Causal Measures of Structure and Plasticity in Simulated and Living Neural Networks

Figure 1

Living Rat Cortical Neurons on a 60 Electrode Microelectrode Array (MEA) from MultiChannel Systems.

A 60 electrode MEA (upper left) used to measure neural activity from a small network of cultured neurons. The upper right corner shows a magnified view of the array consisting of an 8×8 grid of 60 electrodes with living rat cortical neurons at 6 days in vitro. Each electrode is spaced 200 um apart and measures the extracellular potential of neurons nearby the electrode. Example of an extracellular action potential measured with a single electrode (window scale 100 ms×50 uV). Neurons on these arrays are spontaneously active producing synchronized bursts of activity throught their lifetime (up to two years).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0003355.g001