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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Figure 4

Functional gene expression analysis of CR and resveratrol fed mice using SAFE.

A class matrix, which describes the functional categories and specifies what genes are members of what classes, was based on Gene Ontology (GO), and included classes with at least 10 genes, for a total of 571 classes. The SAFE analysis was then run using the default settings for the local statistic (Student's t) and GO terms that differed at P≤0.05 were considered significantly different. Only classes that show a significant effect for at least one treatment in one tissue are shown. Significance values for all functional classes are shown in Supplemental Table S1. Classes highlighted in blue were changed by both CR and resveratrol in all tissues examined.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0002264.g004