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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Figure 3

SIRT1 levels and Pgc1-α transcriptional activity in response to CR and resveratrol.

(A) SIRT1 levels in liver, skeletal muscle and brain (n = at least four animals per group) were determined by Western blot analysis. A loading correction factor based on HSP70 band intensity data was used to normalize the SIRT1 band intensity data. (B) mRNA abundance for known Pgc-1α transcriptional targets is shown for heart, muscle and brain. Data on Y axis represent percentage changes relative to young controls. Results represent n = 5, values in bar graphs are means and SE. * p<0.01.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0002264.g003