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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Figure 2

Effects of CR and resveratrol on physiological parameters.

(A) Cardiac function as determined by transthoracic echocardiography (n = 7, YC, n = 10 OC, n = 8 CR, n = 9 Resv) (B) Serum glucose and plasma IGF-1 in control, CR and resveratrol treated mice (C) Glucose uptake and insulin signaling in control, CR and resveratrol fed animals (n = 16). Rate of 2-deoxyglucose uptake and Akt threonine308 (T308) phosphorylation were determined in isolated paired soleus and extensor digitorum longus (EDL) muscles with or without 0.36 nM insulin. Data were analyzed by two-way ANOVA, and the source of significant variance was tested using Student-Newman-Keuls post-hoc test (n = 15–16 muscles per group). There were no differences between groups at baseline so values shown reflect insulin-stimulated values only. GLUT4 protein abundance was determined in soleus and EDL muscles by western blotting (n = 16 muscles per group). Data were analyzed by one-way ANOVA on ranks, and the source of significant variance was tested using Dunn's post-hoc test.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0002264.g002