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Stylus: A System for Evolutionary Experimentation Based on a Protein/Proteome Model with Non-Arbitrary Functional Constraints

Figure 9

Functional specificity of real proteins depends upon atomic-level details.

The products of the bioF and kbl genes of E. coli are virtually indistinguishable at the fold level, but the structural differences produce different functions. Left: BioF monomer (PDB 1DJE), which functions as a dimer in biotin biosynthesis. Right: Kbl monomer (1FC4), which functions as a dimer in threonine degradation.

Figure 9