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Intense Sweetness Surpasses Cocaine Reward

Figure 4

Pharmacological and economic determinants of cocaine choice.

a, Cocaine-induced locomotion as a function of dose. Locomotion (i.e., mean number of cage crossings±SEM) was measured during 10 min after the first cocaine self-injection of the first day of each dose substitution. b, Choice between levers C and S (mean±SEM) as a function of dose. c, Choice between levers C and S (mean±SEM) as a function of delay between response and saccharin delivery. *, different from the shortest delay (P<0.05, Fisher's LSD test after one-way ANOVA). d, Choice between levers C and S (mean±SEM) as a function of reward price. *, different from the lowest price (P<0.05, Fisher's LSD test after one-way ANOVA). The values of each variable (dose, delay and price) were tested at least 5 times in a row until stabilization of behavior. Bars represent the means of the last 3 stable days.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0000698.g004