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Combinatorial Computational Approaches to Identify Tetracycline Derivatives as Flavivirus Inhibitors

Figure 4

Effects of (A) doxycycline and (B) rolitetracycline on Dengue virus type 2 plaque formation using BHK-21 mammalian cells.

The IC50 values of rolitetracycline and doxytetracycline are 67.1 µM and 55.6 µM, respectively. The x axis shows the percentage of the amount of plaque formation compared with control. The y axis denotes the drug concentration.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0000428.g004