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Experimental Rugged Fitness Landscape in Protein Sequence Space

Figure 4

Emergence of Local Optima in the Landscape.

Each Gaussian-like curve represents the fraction of local optima in the r-th order, (r = 1, 2, 3, 4, 5, 6). Each dashed line represents the relative fitness where the mutation-selection-random drift balance sets in with all conceivable d-fold point mutants of N (d) all (d = 1, 2, 3, 4, 5, 6, 7), given by Eqn. (14). The average local structures at different fitness values are shown schematically.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0000096.g004