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Open Access
Peer-reviewed
Research Article
Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material
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Wendy W. J. de Leng ,
Contributed equally to this work with: Wendy W. J. de Leng, Christa G. Gadellaa-van Hooijdonk, Françoise A. S. Barendregt-Smouter
Affiliation Department of Pathology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Christa G. Gadellaa-van Hooijdonk ,
Contributed equally to this work with: Wendy W. J. de Leng, Christa G. Gadellaa-van Hooijdonk, Françoise A. S. Barendregt-Smouter
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Oncology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Françoise A. S. Barendregt-Smouter ,
Contributed equally to this work with: Wendy W. J. de Leng, Christa G. Gadellaa-van Hooijdonk, Françoise A. S. Barendregt-Smouter
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Marco J. Koudijs,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Ies Nijman,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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John W. J. Hinrichs,
Affiliation Department of Pathology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Edwin Cuppen,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Stef van Lieshout,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Robert D. Loberg,
Affiliation Medical Sciences, Amgen Inc., Thousand Oaks, CA, 91320–1799, United States of America
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Maja de Jonge,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, 3075 EA Rotterdam, The Netherlands
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Emile E. Voest,
Affiliation Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
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Roel A. de Weger,
Affiliation Department of Pathology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Neeltje Steeghs,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
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Marlies H. G. Langenberg,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Oncology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
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Stefan Sleijfer,
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, 3075 EA Rotterdam, The Netherlands
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Stefan M. Willems ,
¶‡ These authors also contributed equally to this work.
Affiliations Department of Pathology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands, Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands
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Martijn P. Lolkema
* E-mail: m.lolkema@erasmusmc.nl
¶‡ These authors also contributed equally to this work.
Affiliations Netherlands Center for Personalized Cancer Treatment, Utrecht, The Netherlands, Department of Medical Oncology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands, Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, 3075 EA Rotterdam, The Netherlands
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Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material
- Wendy W. J. de Leng,
- Christa G. Gadellaa-van Hooijdonk,
- Françoise A. S. Barendregt-Smouter,
- Marco J. Koudijs,
- Ies Nijman,
- John W. J. Hinrichs,
- Edwin Cuppen,
- Stef van Lieshout,
- Robert D. Loberg,
- Maja de Jonge
- Published: February 26, 2016
- https://doi.org/10.1371/journal.pone.0149405