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Open Access
Peer-reviewed
Research Article
CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis
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Shu Zhang ,
Contributed equally to this work with: Shu Zhang, Zhen Lu
Affiliations Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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Zhen Lu ,
Contributed equally to this work with: Shu Zhang, Zhen Lu
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Weiqun Mao,
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Ahmed A. Ahmed,
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Hailing Yang,
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Jinhua Zhou,
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Nicholas Jennings,
Affiliation Departments of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Cristian Rodriguez-Aguayo,
Affiliations Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Center for RNA Interference and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Gabriel Lopez-Berestein,
Affiliations Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Center for RNA Interference and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Roberto Miranda,
Affiliation Departments of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, Untied States of America
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Wei Qiao,
Affiliation Bioinformatics Computer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Veera Baladandayuthapani,
Affiliation Bioinformatics Computer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Zongfang Li,
Affiliation Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, China
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Anil K. Sood,
Affiliations Departments of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Center for RNA Interference and Non-Coding RNA, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Jinsong Liu,
Affiliation Departments of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, Untied States of America
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Xiao-Feng Le ,
* E-mail: rbast@mdanderson.org (RCB); xfle@live.co (XFL)
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Robert C. Bast Jr
* E-mail: rbast@mdanderson.org (RCB); xfle@live.co (XFL)
Affiliation Departments of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis
- Shu Zhang,
- Zhen Lu,
- Weiqun Mao,
- Ahmed A. Ahmed,
- Hailing Yang,
- Jinhua Zhou,
- Nicholas Jennings,
- Cristian Rodriguez-Aguayo,
- Gabriel Lopez-Berestein,
- Roberto Miranda
- Published: July 6, 2015
- https://doi.org/10.1371/journal.pone.0131833