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Open Access
Peer-reviewed
Research Article
Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties
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Mariana Figuera-Losada,
Affiliations Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Marigo Stathis,
Affiliations Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Joelle M. Dorskind,
Affiliations Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Ajit G. Thomas,
Affiliations Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Veera Venkata Ratnam Bandaru,
Affiliations Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Seung-Wan Yoo,
Affiliations Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Nicholas J. Westwood,
Affiliation School of Chemistry and Biomedical Sciences Research Centre, University of Saint Andrews and EaStCHEM, North Haugh, Saint Andrews, Fife, KY16 9ST, United Kingdom
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Graeme W. Rogers,
Affiliation School of Chemistry and Biomedical Sciences Research Centre, University of Saint Andrews and EaStCHEM, North Haugh, Saint Andrews, Fife, KY16 9ST, United Kingdom
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Justin C. McArthur,
Affiliations Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Norman J. Haughey ,
* E-mail: nhaughe1@jhmi.edu (NJH); bslusher@jhmi.edu (BSS); crojas2@jhmi.edu (CR)
Affiliations Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Barbara S. Slusher ,
* E-mail: nhaughe1@jhmi.edu (NJH); bslusher@jhmi.edu (BSS); crojas2@jhmi.edu (CR)
Affiliations Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Camilo Rojas
* E-mail: nhaughe1@jhmi.edu (NJH); bslusher@jhmi.edu (BSS); crojas2@jhmi.edu (CR)
Affiliations Brain Science Institute Drug Discovery Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties
- Mariana Figuera-Losada,
- Marigo Stathis,
- Joelle M. Dorskind,
- Ajit G. Thomas,
- Veera Venkata Ratnam Bandaru,
- Seung-Wan Yoo,
- Nicholas J. Westwood,
- Graeme W. Rogers,
- Justin C. McArthur,
- Norman J. Haughey
- Published: May 26, 2015
- https://doi.org/10.1371/journal.pone.0124481