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Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex
- Masato Kiyoshi,
- Jose M. M. Caaveiro,
- Eri Miura,
- Satoru Nagatoishi,
- Makoto Nakakido,
- Shinji Soga,
- Hiroki Shirai,
- Shigeki Kawabata,
- Kouhei Tsumoto
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- Published: January 27, 2014
- https://doi.org/10.1371/journal.pone.0087099