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Open Access
Peer-reviewed
Research Article
A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1
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Davide Danovi,
Current address: Centre for Stem Cells and Regenerative Medicine, King's College London, London, United Kingdom
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Amos Folarin,
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Sabine Gogolok,
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Christine Ender,
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Ahmed M. O. Elbatsh,
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Pär G. Engström,
Affiliation European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, United Kingdom
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Stefan H. Stricker,
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Sladjana Gagrica,
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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Ana Georgian,
Affiliation Institute of Pharmaceutical Science, King's College London, London, United Kingdom
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Ding Yu,
Affiliation Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Kin Pong U,
Affiliation Institute of Child Health, University College London, London, United Kingdom
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Kevin J. Harvey,
Affiliation EMD Millipore Corporation, San Diego, California, United States of America
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Patrizia Ferretti,
Affiliation Institute of Child Health, University College London, London, United Kingdom
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Patrick J. Paddison,
Affiliation Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Jane E. Preston,
Affiliation Institute of Pharmaceutical Science, King's College London, London, United Kingdom
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N. Joan Abbott,
Affiliation Institute of Pharmaceutical Science, King's College London, London, United Kingdom
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Paul Bertone,
Affiliations European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, United Kingdom, Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, Heidelberg, Germany, Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
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Austin Smith,
Affiliation Wellcome Trust–Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
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Steven M. Pollard
* E-mail: steven.pollard@ed.ac.uk
Current address: MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
Affiliation Samantha Dickson Brain Cancer Unit and Department of Cancer Biology, UCL Cancer Institute, University College London, London, United Kingdom
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A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1
- Davide Danovi,
- Amos Folarin,
- Sabine Gogolok,
- Christine Ender,
- Ahmed M. O. Elbatsh,
- Pär G. Engström,
- Stefan H. Stricker,
- Sladjana Gagrica,
- Ana Georgian,
- Ding Yu
- Published: October 30, 2013
- https://doi.org/10.1371/journal.pone.0077053