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Open Access
Peer-reviewed
Research Article
Pseudotyped AAV Vector-Mediated Gene Transfer in a Human Fetal Trachea Xenograft Model: Implications for In Utero Gene Therapy for Cystic Fibrosis
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Sundeep G. Keswani ,
Contributed equally to this work with: Sundeep G. Keswani, Swathi Balaji, Louis Le
* E-mail: sundeep.keswani@cchmc.org
Affiliations Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Children’s Institute for Surgical Science, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Swathi Balaji ,
Contributed equally to this work with: Sundeep G. Keswani, Swathi Balaji, Louis Le
Affiliation Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
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Louis Le ,
Contributed equally to this work with: Sundeep G. Keswani, Swathi Balaji, Louis Le
Affiliation Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
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Alice Leung,
Affiliation Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
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Anna B. Katz,
Affiliation The Children’s Institute for Surgical Science, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Foong-Yen Lim,
Affiliations Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Children’s Institute for Surgical Science, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Mounira Habli,
Affiliation Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
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Helen N. Jones,
Affiliation Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
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James M. Wilson,
Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
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Timothy M. Crombleholme
Affiliations Center for Molecular Fetal Therapy, Division of Pediatric, General, Thoracic and Fetal Surgery, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Children’s Institute for Surgical Science, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Pseudotyped AAV Vector-Mediated Gene Transfer in a Human Fetal Trachea Xenograft Model: Implications for In Utero Gene Therapy for Cystic Fibrosis
- Sundeep G. Keswani,
- Swathi Balaji,
- Louis Le,
- Alice Leung,
- Anna B. Katz,
- Foong-Yen Lim,
- Mounira Habli,
- Helen N. Jones,
- James M. Wilson,
- Timothy M. Crombleholme
- Published: August 24, 2012
- https://doi.org/10.1371/journal.pone.0043633