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Open Access

Peer-reviewed

Research Article

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis

Sadik H. Kassim,

Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Hui Li,

Affiliation Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Luk H. Vandenberghe,

Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Christian Hinderer,

Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Peter Bell,

Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Dawn Marchadier,

Affiliation Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Aisha Wilson,

Affiliation Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Debra Cromley,

Affiliation Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Valeska Redon,

Affiliation Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Hongwei Yu,

Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
James M. Wilson,

Affiliation Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Daniel J. Rader

* E-mail: rader@mail.med.upenn.edu

Affiliation Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis

Sadik H. Kassim,
Hui Li,
Luk H. Vandenberghe,
Christian Hinderer,
Peter Bell,
Dawn Marchadier,
Aisha Wilson,
Debra Cromley,
Valeska Redon,
Hongwei Yu

x

Published: October 19, 2010
https://doi.org/10.1371/journal.pone.0013424

Reader Comments (2)

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07 Nov 2015
22:39 GMT
Most Recent

Figure #2C Posted by DarilHoff on 07 Nov 2015 at 22:39 GMT
0 Responses

21 Oct 2010
18:49 GMT
Most Recent

Posted by GeneTherapy on 21 Oct 2010 at 18:49 GMT

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Cholesterol
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Mouse models
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Atherosclerosis
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Gene therapy
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Aorta
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Gene transfer
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Familial hypercholesterolemia
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