A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma

Matthew A. Care; Sharon Barrans; Lisa Worrillow; Andrew Jack; David R. Westhead; Reuben M. Tooze

doi:10.1371/journal.pone.0055895

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Open Access

Peer-reviewed

Research Article

A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma

Matthew A. Care,

Affiliations Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Bioinformatics Group, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
⨯
Sharon Barrans,

Affiliation Haematological Malignancy Diagnostic Service (HMDS), St. James’s Institute of Oncology, Leeds, United Kingdom
⨯
Lisa Worrillow,

Affiliation Haematological Malignancy Diagnostic Service (HMDS), St. James’s Institute of Oncology, Leeds, United Kingdom
⨯
Andrew Jack,

Affiliation Haematological Malignancy Diagnostic Service (HMDS), St. James’s Institute of Oncology, Leeds, United Kingdom
⨯
David R. Westhead ,

* E-mail: r.tooze@leeds.ac.uk (RT); D.R.Westhead@leeds.ac.uk (DW)

Affiliation Bioinformatics Group, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
⨯
Reuben M. Tooze

* E-mail: r.tooze@leeds.ac.uk (RT); D.R.Westhead@leeds.ac.uk (DW)

Affiliations Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Haematological Malignancy Diagnostic Service (HMDS), St. James’s Institute of Oncology, Leeds, United Kingdom
⨯

A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma

Matthew A. Care,
Sharon Barrans,
Lisa Worrillow,
Andrew Jack,
David R. Westhead,
Reuben M. Tooze

Published: February 12, 2013
https://doi.org/10.1371/journal.pone.0055895

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Posted by Athena1 on 23 Feb 2013 at 00:48 GMT

Wow! Curious to see what the DLBCL community thinks about this one. Should we be classifying ABC/GCB this way now? Does the biology of these 20 genes mean something since they're the most robustly differentially expressed? Interested to hear everyone's thoughts . . . .

No competing interests declared.

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A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma

A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma

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Posted by Athena1 on 23 Feb 2013 at 00:48 GMT