The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer

Christopher H. Lieu; Hai Tran; Zhi-Qin Jiang; Muling Mao; Michael J. Overman; E. Lin; Cathy Eng; Jeffrey Morris; Lee Ellis; John V. Heymach; Scott Kopetz

doi:10.1371/journal.pone.0077117

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Open Access

Peer-reviewed

Research Article

The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer

Christopher H. Lieu ,

* E-mail: christopher.lieu@ucdenver.edu

Affiliation Division of Medical Oncology, University of Colorado, Denver, Colorado, United States of America
⨯
Hai Tran,

Affiliation Department of Thoracic/Head & Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zhi-Qin Jiang,

Affiliation Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Muling Mao,

Affiliation Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Michael J. Overman,

Affiliation Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
E. Lin,

Affiliation Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Cathy Eng,

Affiliation Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jeffrey Morris,

Affiliation Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Lee Ellis,

Affiliation Department of Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
John V. Heymach,

Affiliation Department of Thoracic/Head & Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Scott Kopetz

Affiliation Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer

Christopher H. Lieu,
Hai Tran,
Zhi-Qin Jiang,
Muling Mao,
Michael J. Overman,
E. Lin,
Cathy Eng,
Jeffrey Morris,
Lee Ellis,
John V. Heymach

Published: October 15, 2013
https://doi.org/10.1371/journal.pone.0077117

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Posted by PLOS_ONE_Group on 01 Nov 2013 at 20:57 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Science Daily
Title: “Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (avastin)”
http://www.sciencedaily.c...

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Competing interests declared: PLOS ONE Staff

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The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer

The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 01 Nov 2013 at 20:57 GMT