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Referee Comments: Referee 1

Posted by PLOS_ONE_Group on 18 Jan 2008 at 19:08 GMT

Referee 1's review:

The work not only elegantly confirms the loss of microvasculature in dSSc but also demonstrates, with pathological techniques in skin of the forearm and trunk, the utility of HSCT in recovering the microvessels.

More details about the patients may be helpful: previous treatments, lung involvement etc.

N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.