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Referee Comments: Referee 1

Posted by PLOS_ONE_Group on 09 Aug 2007 at 22:39 GMT

Reviewer 1's Review

The Authors evaluated the expression of cadherin-9 in various human cell lines and tissue. They conclude that Cadherin-9 represent a novel and reliable surface marker for fibroblast and its presence allow to distiunguish the heterogenic pool of renal fibroblast into resident and activated, immigrate bone marrow derived fibroblast precursor and cells in different stages of epithelial mesenchymal cells. This is an important issue that can surely will help the relative role of E-M transition during the course of nephropathies.

N.B. These are the general comments made by the reviewer when reviewing this paper. Specific points addressed during revision of the paper are not shown.