Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy

Xiao-Li Huang; Zheng Fan; LuAnn Borowski; Robbie B. Mailliard; Morgane Rolland; James I. Mullins; Richard D. Day; Charles R. Rinaldo

doi:10.1371/journal.pone.0012936

Loading metrics

Open Access

Peer-reviewed

Research Article

Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy

Xiao-Li Huang,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Zheng Fan,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
LuAnn Borowski,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Robbie B. Mailliard,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Morgane Rolland,

Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America
⨯
James I. Mullins,

Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America
⨯
Richard D. Day,

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Biostatistics, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Charles R. Rinaldo

* E-mail: rinaldo@pitt.edu

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Biostatistics, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy

Xiao-Li Huang,
Zheng Fan,
LuAnn Borowski,
Robbie B. Mailliard,
Morgane Rolland,
James I. Mullins,
Richard D. Day,
Charles R. Rinaldo

Published: September 23, 2010
https://doi.org/10.1371/journal.pone.0012936

Reader Comments

Post a new comment on this article

Publisher's Note: Error in Results

Posted by PLOS_ONE_Group on 02 Dec 2010 at 23:30 GMT

ELISPOT results for the predicted epitope showed that the 10mer sequence p1722–31 (RPGGKKKYKL) stimulated IFN-γ production without DC in a concentration-dependent manner (Fig. 6A, No DC) at levels approximately 2.5-fold higher than without DC.
http://plosone.org/article/info:doi/10.1371/journal.pone.0012936#article1.body1.sec3.sec5.p1

Data was incorrectly entered. The correct sentence should read: ELISPOT results for the predicted epitope showed that the 10mer sequence p17(22-31) (RPGGKKKYKL) stimulated IFN-gamma production with DC in a concentration-dependent manner at levels approximately 2.5-fold higher than without DC (Fig. 6A, DC compared to No DC).

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Major histocompatibility complex
Is the Subject Area "Major histocompatibility complex" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Antiretroviral therapy
Is the Subject Area "Antiretroviral therapy" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Proteomes
Is the Subject Area "Proteomes" applicable to this article?

Thanks for your feedback.

Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy

Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Publisher's Note: Error in Results

Posted by PLOS_ONE_Group on 02 Dec 2010 at 23:30 GMT