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Butyrate as a Histone Deacetylase Inhibitor (iHDAC)

Posted by DerekS on 15 Aug 2013 at 22:36 GMT

In the discussion section the authors remark that "The decreased oxidation rate of butyrate may result in increased intra-cellular butyrate concentrations in tumor cells, hence causing increased histone deacetylation and subsequently decreased proliferation." This is only partially correct, however, as lower levels of butyrate oxidation can lead to increased intracellular concentrations. The statement is incorrect in that elevated butyrate concentrations will lead to a decrease in histone deacetylation, not an increase. In other words, increases in intracellular concentrations of butyrate lead to HDAC inhibition and likely maintain levels of acetylated histones. Furthermore, butyrate has also been shown to provide the carbon substrate necessary for histone acetyl transferase activity (HAT) which would logically increase the levels of histone acetylation.


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No competing interests declared.