Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents

Christian Hoffmann; Serena Dollive; Stephanie Grunberg; Jun Chen; Hongzhe Li; Gary D. Wu; James D. Lewis; Frederic D. Bushman

doi:10.1371/journal.pone.0066019

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Peer-reviewed

Research Article

Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents

Christian Hoffmann,

Affiliations Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiania, Goiás, Brazil
⨯
Serena Dollive,

Affiliation Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Stephanie Grunberg,

Affiliation Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jun Chen,

Affiliation Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Hongzhe Li,

Affiliations Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Gary D. Wu ,

* E-mail: gdwu@mail.med.upenn.edu (GDW); lewisjd@mail.med.upenn.edu (JDL); bushman@mail.med.upenn.edu (FDB)

Affiliation Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
James D. Lewis ,

* E-mail: gdwu@mail.med.upenn.edu (GDW); lewisjd@mail.med.upenn.edu (JDL); bushman@mail.med.upenn.edu (FDB)

Affiliations Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Frederic D. Bushman

* E-mail: gdwu@mail.med.upenn.edu (GDW); lewisjd@mail.med.upenn.edu (JDL); bushman@mail.med.upenn.edu (FDB)

Affiliation Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents

Christian Hoffmann,
Serena Dollive,
Stephanie Grunberg,
Jun Chen,
Hongzhe Li,
Gary D. Wu,
James D. Lewis,
Frederic D. Bushman

Published: June 17, 2013
https://doi.org/10.1371/journal.pone.0066019

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Human-associated Archaea- the role of Nitrososphaera?

Posted by chmoissl on 02 Jul 2013 at 11:23 GMT

Thank you very much for this very interesting article!

A few days ago our PLOS ONE manuscript "Archaea on human skin" (by Probst, Auerbach and Moissl-Eichinger) was published - and we also found "Nitrososphaera"-relatives to be associated with humans, in particular with human skin.
The independent finding of Thaumarchaeota being part of the human microbiome is certainly a very interesting result. Both studies obtained positive signals from amoA PCR-screening of the samples. However, the role of these Thaumarchaeota remains unclear, but one could speculate about a possible involvement in ammonia turnover on skin or in the gut.
We also stated, that previous studies on the human microbiome may have underestimated the presence and abundance of Thaumarchaeota in human samples - but it seems, specific and sensitive assays as they were used here and in our study, can help to detect the "hidden" Archaea.
I am very excited and I am looking forward to further research on human-associated Archaea!

No competing interests declared.

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Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents

Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents

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Human-associated Archaea- the role of Nitrososphaera?

Posted by chmoissl on 02 Jul 2013 at 11:23 GMT