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Cholesterol genes pre GWAS

Posted by ChrisCarter on 07 Dec 2010 at 23:43 GMT

This study confirms several pre GWAS studies and analyses implicating cholesterol in the pathology of Alzheimer's disease. Many immune related genes had also already been identified http://www.polygenicpathw.... Many such studies were dismissed because of problems of replication, but it now seems that pathway analysis, where multiple gene interactions are taken into account, are confirming previous associations. Sifting through these data may be very informative.

A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.

Papassotiropoulos et al, 2005 http://www.ncbi.nlm.nih.g...

Molecular genetics of Alzheimer's disease and aging.

Cacabelos et al, 2005 http://www.ncbi.nlm.nih.g...

Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis.
Carter 2007 http://www.ncbi.nlm.nih.g...

No competing interests declared.