Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

Graham M. Poage; Brock C. Christensen; E. Andres Houseman; Michael D. McClean; John K. Wiencke; Marshall R. Posner; John R. Clark; Heather H. Nelson; Carmen J. Marsit; Karl T. Kelsey

doi:10.1371/journal.pone.0009651

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Open Access

Peer-reviewed

Research Article

Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

Graham M. Poage,

Affiliation Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America
⨯
Brock C. Christensen,

Affiliations Departments of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America, Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America
⨯
E. Andres Houseman,

Affiliations Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Michael D. McClean,

Affiliation Department of Environmental Health, Boston University, Boston, Massachusetts, United States of America
⨯
John K. Wiencke,

Affiliation Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America
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Marshall R. Posner,

Affiliation Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
John R. Clark,

Affiliation Department of Medicine Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Heather H. Nelson,

Affiliation Division of Epidemiology and Community Health, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Carmen J. Marsit,

Affiliation Departments of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
⨯
Karl T. Kelsey

* E-mail: Karl_Kelsey@Brown.edu

Affiliations Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America, Departments of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America, Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America
⨯

Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

Graham M. Poage,
Brock C. Christensen,
E. Andres Houseman,
Michael D. McClean,
John K. Wiencke,
Marshall R. Posner,
John R. Clark,
Heather H. Nelson,
Carmen J. Marsit,
Karl T. Kelsey

Published: March 11, 2010
https://doi.org/10.1371/journal.pone.0009651

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Array Data

Posted by GMPoage on 20 Mar 2010 at 19:37 GMT

The data discussed in this publication have been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession numbers GSE20742 and GSE20939 (http://www.ncbi.nlm.nih.g...).

No competing interests declared.

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Head and neck squamous cell carcinoma
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Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted

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Array Data

Posted by GMPoage on 20 Mar 2010 at 19:37 GMT