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Body weight

Posted by phemslie on 28 Sep 2012 at 19:49 GMT

Was body weight, and more specifically body fat recorded for the 49 individuals? Is there any relationship between body fat and length/severity of withdrawal symptoms?

No competing interests declared.

RE: Body weight

DoobyDave replied to phemslie on 28 Sep 2012 at 21:46 GMT


This is a great question. We did not measure those variables in this study (we are in our current study) - but there is good reason to think that fat should have some link to levels of free THC in the body - as THC is heavily fat soluble and known to store in fat reserves. However I dont think any work has demonstrated a link between fat and withdrawal severity (remember the brain is a very fatty organ so visible body fat isnt the only place for THC to get stored).
Nevertheless, there is a literature on storage of THC in fat, and its slow release thereafter:

E. Johansson, K. Noren, J. Sjovall, M. M. Halldin, Determination of delta 1-tetrahydrocannabinol in human fat biopsies from marihuana users by gas chromatography-mass spectrometry. Biomedical chromatography : BMC 3, 35 (Jan, 1989).

And the question of whether stimulating fat burning (such as with exercise or fasting) releases THC into the blood and affects withdrawal is an emerging area of research. Good question

Competing interests declared: I am the lead author