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Referee Comments: Referee 1

Posted by PLOS_ONE_Group on 05 May 2008 at 23:46 GMT

Referee 1's Review:

N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication, the manuscript has been revised in light of these comments and to address other editorial requirements.

This is a nice, straightforward, microarray study to characterize purified decidual macrophages in humans. The authors compare decidual macrophages to blood monocytes. Using high stringency criteria, they identify a number of interesting genes that are differentially regulated. The gene expression pattern suggest that alternatively activated macrophages dominate at the maternal/fetal interface. In support of this, many of their upregulated genes are are also upregulated in M2 macrophages in a cited study that compared M2 to M1 activated macrophages.