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The Basis of this Report is Low DHEA

Posted by jamesmhoward on 13 Jul 2012 at 06:57 GMT

The basis of this report is low dehydroepiandrosterone (DHEA). It is my hypothesis of 2004 that low DHEA results in reduced telomeres: "Telomeres, Telomerase, Dehydroepiandrosterone, and Cancer and Aging," at: .

It is also my hypothesis of 1985 that the "fight or flight mechanism" is based on the ratio of DHEA to cortisol. That is, I think DHEA levels determine the amount of motivation an organism brings to a confrontation and cortisol evolved to counteract the effects of DHEA. If cortisol is high enough, then an organism avoids the consequences of a confrontation such as loss of blood, infection, ...death. Evolution would quickly select this mechanism as it would promote future reproduction of more organisms and fighting would reduce reproduction.

This is derived from my examination of the adrenal hormone pathways in 1984. It became apparent to me quickly that there really are mainly two pathways of major amounts of hormone production, that is, DHEA and cortisol. Anxiety is the result of unresolved fight or flight, that is, the cortisol level overwhelms the DHEA level.

I suggest the findings of Okereke, et al., may be explained by low levels of DHEA.

No competing interests declared.