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Another potential use...

Posted by iyudushkin on 14 Sep 2007 at 01:05 GMT

Certain organic dyes, including some widely used rhodamine-, BODIPY- and indocyanine-based fluorophores, sometimes exhibit unspecific sorption on cellular structures when used for live- or fixed-cell imaging. A short peptide that appears to interact with nanomolar affinity with certain fluorophores, such as the one reported in this study, would be an excellent washing reagent to decrease unspecific dye sorption and eliminate the background staining (as demonstrated in a competition expt in Fig. 6A).