Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis

Farrel J. Buchinsky; Joseph Donfack; Craig S. Derkay; Sukgi S. Choi; Stephen F. Conley; Charles M. Myer III; John E. McClay; Paolo Campisi; Brian J. Wiatrak; Steven E. Sobol; John M. Schweinfurth; Domingos H. Tsuji; Fen Z. Hu; Howard E. Rockette; Garth D. Ehrlich; J. Christopher Post

doi:10.1371/journal.pone.0002263

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Peer-reviewed

Research Article

Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis

Farrel J. Buchinsky ,

* E-mail: fjbuch@gmail.com

Affiliation Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
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Joseph Donfack,

Affiliation Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
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Craig S. Derkay,

Affiliation Eastern Virginia Medical School, Norfolk, Virginia, United States of America
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Sukgi S. Choi,

Affiliation Children's National Medical Center, Washington, DC, United States of America
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Stephen F. Conley,

Affiliation Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America
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Charles M. Myer III,

Affiliation Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
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John E. McClay,

Affiliation Children's Medical Center of Dallas, Dallas, Texas, United States of America
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Paolo Campisi,

Affiliation The Hospital for Sick Children, Toronto, Ontario, Canada
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Brian J. Wiatrak,

Affiliation Children's Hospital of Alabama, Birmingham, Alabama, United States of America
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Steven E. Sobol,

Affiliation Emory University School of Medicine, Atlanta, Georgia, United States of America
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John M. Schweinfurth,

Affiliation University of Mississippi Medical Center, Jackson, Mississippi, United States of America
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Domingos H. Tsuji,

Affiliation Hospital das Clinicas of Sao Paulo University Medical School, Sao Paulo, Brazil
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Fen Z. Hu,

Affiliations Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Departments of Human Genetics, and Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
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Howard E. Rockette,

Affiliation Biostatistics Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Garth D. Ehrlich,

Affiliations Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Departments of Human Genetics, and Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
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[ ... ],
J. Christopher Post

Affiliations Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Departments of Human Genetics, and Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
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Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis

Farrel J. Buchinsky,
Joseph Donfack,
Craig S. Derkay,
Sukgi S. Choi,
Stephen F. Conley,
Charles M. Myer III,
John E. McClay,
Paolo Campisi,
Brian J. Wiatrak,
Steven E. Sobol

Published: May 28, 2008
https://doi.org/10.1371/journal.pone.0002263

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Seedat RY did not observe age-type association

Posted by Farrel on 01 May 2010 at 08:05 GMT

the average age of diagnosis amongst those with HPV 6 was 3.4 years and the average age of diagnosis for those with HPV 11 was 2.4 years (t test p-value = 0.014)
http://plosone.org/article/info:doi/10.1371/journal.pone.0002263#article1.body1.sec2.p8

Seedat et al, analyzed 18 patients and found that the average age of diagnosis amongst those with HPV 6 was 5.4 years and for those with HPV 11 it was 5.3 years. Possible reasons: 1)smaller sample size 2)generally later diagnosis 3)truly different pattern for inexplicable reasons.

see: HPV types causing juvenile recurrent laryngeal papillomatosis in South Africa.
Seedat RY, Thukane M, Jansen AC, Rossouw I, Goedhals D, Burt FJ.
Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):255-9.
PMID: 20018386

No competing interests declared.

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Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis

Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis

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Seedat RY did not observe age-type association

Posted by Farrel on 01 May 2010 at 08:05 GMT