Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Tiago Fleming Outeiro; Preeti Putcha; Julie E. Tetzlaff; Robert Spoelgen; Mirjam Koker; Filipe Carvalho; Bradley T. Hyman; Pamela J. McLean

doi:10.1371/journal.pone.0001867

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Open Access

Peer-reviewed

Research Article

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Tiago Fleming Outeiro ,

* E-mail: touteiro@fm.ul.pt (TO); pmclean@partners.org (PM)

Affiliations Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America, Instituto de Medicina Molecular, Cell and Molecular Neuroscience Unit, Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
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Preeti Putcha,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Julie E. Tetzlaff,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Robert Spoelgen,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Mirjam Koker,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Filipe Carvalho,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Bradley T. Hyman,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Pamela J. McLean

* E-mail: touteiro@fm.ul.pt (TO); pmclean@partners.org (PM)

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Tiago Fleming Outeiro,
Preeti Putcha,
Julie E. Tetzlaff,
Robert Spoelgen,
Mirjam Koker,
Filipe Carvalho,
Bradley T. Hyman,
Pamela J. McLean

Published: April 2, 2008
https://doi.org/10.1371/journal.pone.0001867

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A useful model

Posted by Diego_Albani on 09 Apr 2008 at 12:24 GMT

A good work that depicts a useful tool for analyzing oligomers formation in Parkinson's disease but also in other neurodegenerative diseases.

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Oligomers
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Transfection
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Parkinson disease
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Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

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A useful model

Posted by Diego_Albani on 09 Apr 2008 at 12:24 GMT