Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

Open Access

Peer-reviewed

Research Article

Taras K. Oleksyk ,

*E-mail: oleksyk@ncifcrf.gov

Affiliations Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Kai Zhao,

Affiliation Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Francisco M. De La Vega,

Affiliation Applied Biosystems, Foster City, California, United States of America
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Dennis A. Gilbert,

Affiliation Applied Biosystems, Foster City, California, United States of America
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Stephen J. O'Brien,

Affiliation Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Michael W. Smith

Affiliations Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
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Reader Comments

An “old” selection event
http://plosone.org/article/info:doi/10.1371/journal.pone.0001712#article1.body1.sec2.sec3.p1

This selection signature is likely to be older then the date of separation between African and European populations. Other studies implicated CCR5 as a target of much more recent selection (<1000 years).

Single nucleotide polymorphisms
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Heterozygosity
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African American people
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Genetic loci
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Human genomics
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Genomics
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