IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

Silvia Lorenzi; Matteo Forloni; Loredana Cifaldi; Chiara Antonucci; Arianna Citti; Renata Boldrini; Marco Pezzullo; Aurora Castellano; Vincenzo Russo; Pierre van der Bruggen; Patrizio Giacomini; Franco Locatelli; Doriana Fruci

doi:10.1371/journal.pone.0046928

Loading metrics

Open Access

Peer-reviewed

Research Article

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

Silvia Lorenzi ,

Contributed equally to this work with: Silvia Lorenzi, Matteo Forloni

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Matteo Forloni ,

Contributed equally to this work with: Silvia Lorenzi, Matteo Forloni

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Loredana Cifaldi,

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Chiara Antonucci,

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Arianna Citti,

Affiliation Pathology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Renata Boldrini,

Affiliation Pathology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Marco Pezzullo,

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Aurora Castellano,

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯
Vincenzo Russo,

Affiliation Cancer Gene Therapy Unit, Scientific Institute San Raffaele, Milan, Italy
⨯
Pierre van der Bruggen,

Affiliation Laboratory of Immunology CRS, Regina Elena National Cancer Institute, Rome, Italy
⨯
Patrizio Giacomini,

Affiliation Ludwig Institute for Cancer Research and Université Catholique de Louvain, de Duve Institute, Brussels, Belgium
⨯
Franco Locatelli,

Affiliations Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy, University of Pavia, Pavia, Italy
⨯
Doriana Fruci

* E-mail: fruci@opbg.net

Affiliation Paediatric Haematology/Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
⨯

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

Silvia Lorenzi,
Matteo Forloni,
Loredana Cifaldi,
Chiara Antonucci,
Arianna Citti,
Renata Boldrini,
Marco Pezzullo,
Aurora Castellano,
Vincenzo Russo,
Pierre van der Bruggen

Published: October 5, 2012
https://doi.org/10.1371/journal.pone.0046928

Reader Comments

Post a new comment on this article

The affiliations of Patrizio Giacomini and Pierre van der Bruggen were mistakenly exchanged.

Posted by dorianafruci on 31 Jan 2013 at 11:34 GMT

Please note that Patrizio Giacomini works at the Laboratory of Immunology CRS, Regina Elena National Cancer Institute, Rome, Italy, whereas Pierre van der Bruggen's affiliation should read: Ludwig Institute for Cancer Research and Universite´ Catholique de Louvain, de Duve Institute, Brussels, Belgium.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Cancer immunotherapy
Is the Subject Area "Cancer immunotherapy" applicable to this article?

Thanks for your feedback.
Antigen presentation
Is the Subject Area "Antigen presentation" applicable to this article?

Thanks for your feedback.
Antigen processing and recognition
Is the Subject Area "Antigen processing and recognition" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Immunohistochemistry techniques
Is the Subject Area "Immunohistochemistry techniques" applicable to this article?

Thanks for your feedback.
Melanoma cells
Is the Subject Area "Melanoma cells" applicable to this article?

Thanks for your feedback.

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

The affiliations of Patrizio Giacomini and Pierre van der Bruggen were mistakenly exchanged.

Posted by dorianafruci on 31 Jan 2013 at 11:34 GMT