TY - JOUR T1 - Physical Properties of Biological Entities: An Introduction to the Ontology of Physics for Biology A1 - Cook, Daniel L. A1 - Bookstein, Fred L. A1 - Gennari, John H. Y1 - 2011/12/27 N2 - As biomedical investigators strive to integrate data and analyses across spatiotemporal scales and biomedical domains, they have recognized the benefits of formalizing languages and terminologies via computational ontologies. Although ontologies for biological entities—molecules, cells, organs—are well-established, there are no principled ontologies of physical properties—energies, volumes, flow rates—of those entities. In this paper, we introduce the Ontology of Physics for Biology (OPB), a reference ontology of classical physics designed for annotating biophysical content of growing repositories of biomedical datasets and analytical models. The OPB's semantic framework, traceable to James Clerk Maxwell, encompasses modern theories of system dynamics and thermodynamics, and is implemented as a computational ontology that references available upper ontologies. In this paper we focus on the OPB classes that are designed for annotating physical properties encoded in biomedical datasets and computational models, and we discuss how the OPB framework will facilitate biomedical knowledge integration. JF - PLOS ONE JA - PLOS ONE VL - 6 IS - 12 UR - https://doi.org/10.1371/journal.pone.0028708 SP - e28708 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pone.0028708 ER -