TY - JOUR T1 - SNPs in the FCER1A Gene Region Show No Association with Allergic Rhinitis in a Han Chinese Population A1 - Zhang, Yuan A1 - Duan, Su A1 - Lin, Xiaoping A1 - Zhang, Wei A1 - Meng, Na A1 - Zhao, Liping A1 - Zhao, Yan A1 - Han, Demin A1 - Zhang, Luo Y1 - 2011/12/31 N2 - Background Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. Methodology/Principal Findings A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. Conclusions Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility. JF - PLOS ONE JA - PLOS ONE VL - 5 IS - 12 UR - https://doi.org/10.1371/journal.pone.0015792 SP - e15792 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pone.0015792 ER -