Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

Kazutoshi Yamada; Eishiro Mizukoshi; Takuya Seike; Rika Horii; Masaaki Kitahara; Hajime Sunagozaka; Kuniaki Arai; Tatsuya Yamashita; Masao Honda; Shuichi Kaneko

doi:10.1371/journal.pone.0191026

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Open Access

Peer-reviewed

Research Article

Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

Kazutoshi Yamada,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

http://orcid.org/0000-0002-4611-448X

⨯
Eishiro Mizukoshi ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: eishirom@m-kanazawa.jp

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Takuya Seike,

Roles Investigation

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Rika Horii,

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Masaaki Kitahara,

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Hajime Sunagozaka,

Roles Conceptualization, Investigation, Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Kuniaki Arai,

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Tatsuya Yamashita,

Roles Investigation

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Masao Honda,

Roles Formal analysis, Project administration, Software, Supervision

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯
Shuichi Kaneko

Roles Conceptualization, Funding acquisition, Project administration, Supervision

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
⨯

Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

Kazutoshi Yamada,
Eishiro Mizukoshi,
Takuya Seike,
Rika Horii,
Masaaki Kitahara,
Hajime Sunagozaka,
Kuniaki Arai,
Tatsuya Yamashita,
Masao Honda,
Shuichi Kaneko

Published: January 17, 2018
https://doi.org/10.1371/journal.pone.0191026

About the Authors

Kazutoshi Yamada

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

http://orcid.org/0000-0002-4611-448X

Eishiro Mizukoshi

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: eishirom@m-kanazawa.jp

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Takuya Seike

Roles Investigation

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Rika Horii

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Masaaki Kitahara

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Hajime Sunagozaka

Roles Conceptualization, Investigation, Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Kuniaki Arai

Roles Resources

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Tatsuya Yamashita

Roles Investigation

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Masao Honda

Roles Formal analysis, Project administration, Software, Supervision

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Shuichi Kaneko

Roles Conceptualization, Funding acquisition, Project administration, Supervision

Affiliation Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Competing Interests

The authors have declared that no competing interests exist.

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Alcohol consumption
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Fatty liver
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Inflammation
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Gene expression
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Fibrosis
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Cytokines
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Microarrays
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Liver fibrosis
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