About the Authors

Jen-Chieh Tseng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

Jen-Chieh.Tseng@perkinelmer.com

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Nara Narayanan

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Guojie Ho

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Kevin Groves

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Jeannine Delaney

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Bagna Bao

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Jun Zhang

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Jeffrey Morin

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Sylvie Kossodo

Roles Methodology, Resources

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Milind Rajopadhye

Roles Methodology, Resources, Supervision

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Jeffrey D. Peterson

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation Discovery & Analytical Solutions R&D, PerkinElmer Inc., Hopkinton, Massachusetts, United States of America

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: All authors are employed by PerkinElmer. PerkinElmer currently holds patents for the technology used in these studies, and the research documents the utility of PerkinElmer imaging agents, optical imaging technology and microPET imaging technology in establishing a robust quantitative technique for imaging tumor changes in metabolic activity. PerkinElmer expects to further increase scientific interest in optical imaging technology and molecular imaging in general. The authors hold no patents relevant to the manuscript, and no patent applications are being submitted (or are planned to be submitted). No reimbursement or funding relating to potential patents has been received. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.