About the Authors

Tom van den Bergh

Contributed equally to this work with: Tom van den Bergh, Giorgio Tamo

Affiliations Bio-Prodict, Nijmegen, The Netherlands, Laboratory of Systems and Synthetic Biology, Wageningen University, Wageningen, The Netherlands

Giorgio Tamo

Contributed equally to this work with: Tom van den Bergh, Giorgio Tamo

Current address: Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Affiliation Bio-Prodict, Nijmegen, The Netherlands

Alberto Nobili

Affiliation Institute of Biochemistry, Department of Biotechnology & Enzyme Catalysis, Greifswald University, Greifswald, Germany

Yifeng Tao

Affiliations Institute of Biochemistry, Department of Biotechnology & Enzyme Catalysis, Greifswald University, Greifswald, Germany, Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology, Chaoyang, Beijing, China

Tianwei Tan

Affiliation Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology, Chaoyang, Beijing, China

Uwe T. Bornscheuer

Affiliation Institute of Biochemistry, Department of Biotechnology & Enzyme Catalysis, Greifswald University, Greifswald, Germany

Remko K. P. Kuipers

Affiliation Bio-Prodict, Nijmegen, The Netherlands

Bas Vroling

Affiliation Bio-Prodict, Nijmegen, The Netherlands

René M. de Jong

Affiliation DSM Biotechnology Center, Delft, The Netherlands

Kalyanasundaram Subramanian

Affiliation Laboratory of Systems and Synthetic Biology, Wageningen University, Wageningen, The Netherlands

Peter J. Schaap

Affiliation Laboratory of Systems and Synthetic Biology, Wageningen University, Wageningen, The Netherlands

Tom Desmet

Affiliation Centre for Industrial Biotechnology and Biocatalysis, Ghent University, Ghent, Belgium

Bernd Nidetzky

Affiliation Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Graz, Austria

Gert Vriend

Affiliation CMBI, Radboudumc, Nijmegen, The Netherlands

Henk-Jan Joosten

joosten@bio-prodict.nl

Affiliations Bio-Prodict, Nijmegen, The Netherlands, CMBI, Radboudumc, Nijmegen, The Netherlands

Competing Interests

HJ has competing financial interests, as he owns the company Bio-Prodict. TB, RK and BV are employed by and receive salaries from Bio-Prodict. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: TB HJ RJ BV. Data curation: TB RK. Formal analysis: TB. Funding acquisition: HJ UB. Investigation: TB KS AN TD YT TT RK. Methodology: TB GT BV. Project administration: HJ. Resources: HJ YT TT UB TD BN. Supervision: HJ PS UB GV. Validation: TB AN YT. Visualization: TB. Writing – original draft: TB GT. Writing – review & editing: TB GT AN.