About the Authors

Tomoko Yamashita

yamashita.tomoko@md.mt-pharma.co.jp

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Yuki Miyamoto

Affiliation Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan

Yoshio Bando

Affiliation Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Hokkaido, Japan

Takashi Ono

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Sakurako Kobayashi

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Ayano Doi

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Toshihiro Araki

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Yosuke Kato

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Takayuki Shirakawa

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Yutaka Suzuki

Affiliation Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan

Junji Yamauchi

Affiliation Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan

Shigetaka Yoshida

Affiliation Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Hokkaido, Japan

Naoya Sato

Affiliations Discovery Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, MP Healthcare Venture Management, Boston, Massachusetts, United States of America

Competing Interests

TY, TO, SK, AD, TA, YK, TS, YS and NS are employed by Mitsubishi Tanabe Pharma Corporation. This study was also funded by Mitsubishi Tanabe Pharma Corporation. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: TY NS. Data curation: TY YM YB. Formal analysis: TY. Funding acquisition: NS. Investigation: TY YM YB TO SK AD TA YK TS YS. Methodology: TY YS NS. Project administration: NS. Supervision: NS. Validation: TY YM YB. Visualization: TY YM YB JY SY NS. Writing – original draft: TY. Writing – review & editing: TY JY SY NS.