About the Authors

Maria Teresa Pagliari

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Luca A. Lotta

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Hugoline G. de Haan

Affiliation Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Carla Valsecchi

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Gloria Casoli

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Silvia Pontiggia

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Ida Martinelli

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Serena M. Passamonti

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy

Frits R. Rosendaal

Affiliation Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Flora Peyvandi

flora.peyvandi@unimi.it

Affiliations Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

Competing Interests

F. Peyvandi has received honoraria for participating as a speaker at satellite symposia and educational meetings organized by Bayer, Biotest, CSL Behring, Grifols, Novo Nordisk, and Sobi. She is recipient of research grant funding from Alexion, Biotest, Kedrion Biopharma, and Novo Nordisk received by Fondazione Luigi Villa, and she has received consulting fees from Kedrion Biopharma, LFB and Octapharma. She is a member of the Ablynx scientific advisory board. The other authors do not have any conflict of interests to disclose. The above statement does not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: FP LAL MTP FRR. Formal analysis: HGH LAL MTP. Investigation: MTP CV GC SP HGH. Resources: IM SMP FP FRR. Writing – original draft: MTP FP HGH LAL FRR. Writing – review & editing: MTP FP FRR HGH IM SMP.