About the Authors
- Robert A. Wise
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
* E-mail: rwise@jhmi.edu
Affiliation Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
- Janet T. Holbrook
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Gerard Criner
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Temple University, Philadelphia, Pennsylvania, United States of America
- Sanjay Sethi
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation University at Buffalo, SUNY and VA WNY Healthcare system, Buffalo, New York, United States of America
- Sobharani Rayapudi
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Kuladeep R. Sudini
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Elizabeth A. Sugar
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Alyce Burke
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Rajesh Thimmulappa
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Anju Singh
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- Paul Talalay
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
- Jed W. Fahey
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America
- Charles S. Berenson
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation University at Buffalo, SUNY and VA WNY Healthcare system, Buffalo, New York, United States of America
- Michael R. Jacobs
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Temple University, Philadelphia, Pennsylvania, United States of America
- Shyam Biswal
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Contributed equally to this work with: Robert A. Wise, Janet T. Holbrook, Gerard Criner, Sanjay Sethi, Sobharani Rayapudi, Kuladeep R. Sudini, Elizabeth A. Sugar, Alyce Burke, Rajesh Thimmulappa, Anju Singh, Paul Talalay, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Shyam Biswal
Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- on behalf of Broccoli Sprout Extract Trial Research Group
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¶Membership of the Broccoli Sprout Extract Trial Research Group is provided in the Acknowledgments.
Competing Interests
Dr. Wise reports grants and personal fees from Boehringer Ingelhelm, Sunovion, and AstraZeneca/Medimmune, and personal fees from Bristol-Myers-Squibb, GlaxoSmithKline, Mylan, Novartis, Pfizer, Pulmonx, Spiration, Roche/Genentech, Janssen, Merck, Teva, Forest Labs, and Sanofi/Mannkind, outside of submitted work. Drs. Fahey and Talalay report multiple US and foreign issued patents related to broccoli sprouts and sulforaphane. Dr. Biswal reports a pending patent on methods for targeting Nrf2 pathway for oxidative stress related disease. The relevant patents held by Drs. Fahey, Talalay and Biswal are listed below. Drs. Fahey and Talalay have relinquished all ownership and any fiduciary or management involvement in Brassica Protection Products (BPP). They are no longer either Board Members or equity holders. In addition, they have instructed JHU NOT to collect the ‘inventor’s share’ of any royalties that may accrue to JHU from the patents originating with their work on broccoli sprouts, licensed to BPP or anyone else. This does not alter our adherence to PLOS ONE policies on sharing data and materials. 1998 Fahey JW, P Talalay."Method of Preparing a Food Product from Cruciferous Seeds". U.S. Patent 5,725,895. 1999 Fahey JW, P Talalay. “Cancer Chemoprotective Food Products.” U.S. Patent 5,968,505. 1999 Fahey JW, P Talalay. “Method of Preparing a Food Product From Cruciferous Sprouts.” U.S. Patent 5,968,567. 2001 Fahey JW, P Talalay. “Method of Preparing a Food Product From Cruciferous Sprouts.” U.S. Patent 6,177,122. 2001 Fahey JW, P Talalay. “Cancer Chemoprotective Food Products.” U.S. Patent 6,242,018. 2001 Fahey JW, P Talalay, J Troyer. Airlift Bioreactor for Harvesting Sprouts. U.S. Patent Application 09/450,753 and PCT WO 01/39591 A2. 2003 Fahey JW. Development of Novel, Highly Chemoprotectant Crucifer Germplasm. U.S. Patent 6,521,818. 2004 Fahey JW. Treatment of Helicobacter with Isothiocyanates. U.S. Patent 6,737,441. 2004 Fahey JW. Method for the direct extraction of isothiocyanates into the seed oil from glucosinolate-containing plant seeds. U.S. Provisional Patent Application # 60/635,998 and U.S. Patent Application (2005). 2007 Fahey JW and P Talalay. “Cancer Chemoprotective Food Products.” U.S. Patent 7,303,770 B2. 2008 Fahey JW. Treatment of Helicobacter with Isothiocyanates. U.S. Patent 7,402,569. 2010 Talalay P, JW Fahey, A Talalay. Formulations for Treatment with Glucosinolates. U.S. Provisional Patent Application #61/383,853.
Author Contributions
Conceptualization: RAW SB PT. Data curation: JTH EAS AB. Formal analysis: EAS AB JTH. Funding acquisition: RAW SB. Investigation: SR KRS JWF RT AS. Methodology: JTH SR KRS EAS AB RT AS JWF. Project administration: RAW JTH SB GC SS JWF. Resources: RAW JTH SB GC SS JWF. Supervision: RAW JTH GC SS RT CSB MRJ SB. Validation: JF. Visualization: EAS AB. Writing – original draft: RAW JTH. Writing – review & editing: RAW JTH GC SS SR KRS EAS AB RT AS PT JWF CSB MRJ SB.