About the Authors

Antonietta Stellavato

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Luisana Corsuto

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Antonella D’Agostino

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Annalisa La Gatta

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Paola Diana

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Patrizia Bernini

Affiliation IBSA Farmaceutici Italia Srl, Lodi, Italy

Mario De Rosa

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Chiara Schiraldi

chiara.schiraldi@unina2.it

Affiliation Department of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Second University of Naples, Bioteknet, Naples, Italy

Competing Interests

CS, MDR, ADA and ALG are inventors of a patent on hybrid cooperative complexes, while a company is the assignee. PB is affiliated with IBSA as Medical Marketing. She contributed in the initial design of the experimental work and support with the company the English final copyediting. IBSA also supplies reagents and material for the study but did not have any other additional role in, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: CS MDR AS PB. Formal analysis: AS LC ADA ALG PD. Funding acquisition: CS MDR. Investigation: AS LC ADA ALG PD CS. Methodology: AS LC ADA ALG PD. Project administration: CS MDR. Resources: CS MDR. Software: AS LC ADA ALG PD. Supervision: CS MDR. Validation: AS LC ADA ALG PD CS. Writing – original draft: AS CS. Writing – review & editing: AS ALG ADA PB CS.