About the Authors

Jen-Hsin Kao

Affiliations Department of Medical Research, Cathay General Hospital, Taipei, Taiwan, Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan

Sheng-Hsiung Lin

Affiliation Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan

Chun-Fu Lai

Affiliations Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Department of Family Medicine, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan

Yu-Chieh Lin

Affiliations Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Department of Pathology, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan; National Defense Medical Center, Taipei, Taiwan

Zwe-Ling Kong

Affiliation Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan

Chih-Shung Wong

w82556@gmail.com

Affiliations Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan, Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan

Competing Interests

The authors were contracted by Universal Integrated Corp., a commercial company located in Taipei, Taiwan, to study the effect of the product SheaFlex75 on their well-established OA animal model, ACLT plus MMx. Additionally, neither we nor any of our team members received any extra financial support outside of that stated in the Financial Disclosure, and none of our research team members are company consultants or own patents and benefits from the product’s sales. There are no products in development to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JHK CSW. Performed the experiments: JHK ZLK. Analyzed the data: JHK SHL. Contributed reagents/materials/analysis tools: JHK CFL YCL. Wrote the paper: JHK CSW.