Investigate the Metabolic Reprogramming of Saccharomyces cerevisiae for Enhanced Resistance to Mixed Fermentation Inhibitors via 13C Metabolic Flux Analysis

Weihua Guo; Yingying Chen; Na Wei; Xueyang Feng

doi:10.1371/journal.pone.0161448

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Open Access

Peer-reviewed

Research Article

Investigate the Metabolic Reprogramming of Saccharomyces cerevisiae for Enhanced Resistance to Mixed Fermentation Inhibitors via ¹³C Metabolic Flux Analysis

Weihua Guo,

Affiliation Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States of America
⨯
Yingying Chen,

Affiliation Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame, Notre Dame, IN 46556, United States of America
⨯
Na Wei ,

* E-mail: nwei@nd.edu (NW); xueyang@vt.edu (XF)

Affiliation Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame, Notre Dame, IN 46556, United States of America
⨯
Xueyang Feng

* E-mail: nwei@nd.edu (NW); xueyang@vt.edu (XF)

Affiliation Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States of America
⨯

Investigate the Metabolic Reprogramming of Saccharomyces cerevisiae for Enhanced Resistance to Mixed Fermentation Inhibitors via ¹³C Metabolic Flux Analysis

Weihua Guo,
Yingying Chen,
Na Wei,
Xueyang Feng

Published: August 17, 2016
https://doi.org/10.1371/journal.pone.0161448

About the Authors

Weihua Guo

Affiliation Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States of America

Yingying Chen

Affiliation Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame, Notre Dame, IN 46556, United States of America

Na Wei

* E-mail: nwei@nd.edu (NW); xueyang@vt.edu (XF)

Affiliation Department of Civil and Environmental Engineering and Earth Sciences, University of Notre Dame, Notre Dame, IN 46556, United States of America

Xueyang Feng

* E-mail: nwei@nd.edu (NW); xueyang@vt.edu (XF)

Affiliation Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: XF NW. Methodology: WG YC NW XF. Writing - original draft: WG YC. Writing - review & editing: WG YC NW XF.

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Acetic acid
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Saccharomyces cerevisiae
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Yeast
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Glucose
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Fermentation
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Glucose metabolism
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Citric acid cycle
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Glycolysis
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