About the Authors

René-Maxime Gracien

Rene-Maxime.Gracien@kgu.de

Affiliations Department of Neurology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Alina Jurcoane

Affiliations Department of Neuroradiology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Marlies Wagner

Affiliations Department of Neuroradiology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Sarah C. Reitz

Affiliations Department of Neurology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Christoph Mayer

Affiliation Department of Neurology, Goethe University, Frankfurt/Main, Germany

Steffen Volz

Affiliation Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Stephanie-Michelle Hof

Affiliations Department of Neurology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Vinzenz Fleischer

Affiliations Department of Neurology, Johannes Gutenberg University, Mainz, Germany, Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg-University, Mainz, Germany

Amgad Droby

Affiliations Department of Neurology, Johannes Gutenberg University, Mainz, Germany, Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg-University, Mainz, Germany

Helmuth Steinmetz

Affiliation Department of Neurology, Goethe University, Frankfurt/Main, Germany

Frauke Zipp

Affiliations Department of Neurology, Johannes Gutenberg University, Mainz, Germany, Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg-University, Mainz, Germany

Elke Hattingen

Affiliations Department of Neuroradiology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Ralf Deichmann

Affiliation Brain Imaging Center, Goethe University, Frankfurt/Main, Germany

Johannes C. Klein

Affiliations Department of Neurology, Goethe University, Frankfurt/Main, Germany, Brain Imaging Center, Goethe University, Frankfurt/Main, Germany, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Competing Interests

The authors report no conflicts of interest relevant to this study. Dr RM Gracien went to an MS-related training to London in 2013 sponsored by Roche. Dr H Steinmetz has received speaker’s honoraria from Bayer, Sanofi and Boehringer Ingelheim. Dr F Zipp has received research grants from Teva, Merck Serono, Novartis and Bayer, as well as consultation fees from Teva, Merck Serono, Novartis, Bayer Healthcare, Biogen Idec Germany, ONO, Genzyme, Sanofi-Aventis and Octapharma. She has received travel compensation from the aforementioned companies. Dr JC Klein received speaker honoraria and travel reimbursement from Medtronic, AstraZeneca, Abbott Laboratories and AbbVie. Dr C Mayer has received honoraria for speaking/consultation and travel grants from Bayer Healthcare, Biogen Idec, Merck Serono, Genzyme, a Sanofi Company, Novartis Pharmaceuticals and Teva Pharma GmbH and research grants from Novartis Pharmaceuticals. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: R-MG AJ MW SCR CM SV S-MH VF AD HS FZ EH RD JCK. Performed the experiments: R-MG AJ MW SCR S-MH. Analyzed the data: R-MG RD JCK. Contributed reagents/materials/analysis tools: R-MG AJ MW SCR RD JCK. Wrote the paper: R-MG AJ MW SCR CM SV S-MH VF AD HS FZ EH RD JCK.